The schizotypy-related subcortical volume pattern was negatively correlated with subcortical abnormalities in SZ (rho=-.65, p spin=.01), BD (rho=-.63, p spin=.01), and MDD (rho=-.69, p spin=.004). The cortical thickness profile in schizotypy was positively correlated with cortical abnormalities in SZ (r=.33, p spin=.01), but not BD (r=.19, p spin=.16) or MDD (r=-.22, p spin=.10). Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r=.07, p FDR=.02). Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. The sample comprised 3,004 unmedicated healthy individuals (12-68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group.
The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis.
Thompson, André Aleman, View ORCID Profile Gemma Modinos Park, Kristina Wiebels, Imke Lemmers-Jansen, James Gilleen, Paul Allen, Petya Kozhuharova, Jan-Bernard Marsman, Irina Lebedeva, Alexander Tomyshev, Anna Mukhorina, Stefan Kaiser, Anne-Kathrin Fett, Iris Sommer, Sanne Schuite-Koops, Casey Paquola, Sara Larivière, Boris Bernhardt, Alain Dagher, Phillip Grant, Theo G. Baune, Melissa Green, Yann Quidé, Christos Pantelis, Raymond Chan, Yi Wang, Ulrich Ettinger, Martin Debbané, Melodie Derome, Christian Gaser, Bianca Besteher, Kelly Diederen, Tom J Spencer, Paul Fletcher, Wulf Rössler, Lukasz Smigielski, Veena Kumari, Preethi Premkumar, Haeme R. Leehr, Joscha Böhnlein, Marius Gruber, David Mehler, Pamela DeRosse, Ashley Moyett, Bernhard T. View ORCID Profile Matthias Kirschner, Benazir Hodzic-Santor, Mathilde Antoniades, Igor Nenadic, Tilo Kircher, Axel Krug, Tina Meller, Dominik Grotegerd, Alex Fornito, Aurina Arnatkeviciute, Mark A Bellgrove, Jeggan Tiego, Udo Dannlowski, Katharina Koch, Carina Hülsmann, Harald Kugel, Verena Enneking, Melissa Klug, Elisabeth J.
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